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T2DM Pharmacology

Across
The most common side effect of metformin.
Brand name for canagliflozin.
This class of medications is contraindicated in patients with advanced stages of heart failure.
The main mechanism of action of SGLT-2 inhibitors is inhibiting glucose (blank) in the kidneys.
This medication is contraindicated in patients with an eGFR <30mL/min/1.73m2 due to increased risk for lactic acidosis.
This class of oral medications are only taken with meals and the dose is skipped when a patient doesn't eat a meal.
This medication is the only one of the DPP4 inhibitors that doesn't require renal adjustment.
The mechanism of action of this class of medications is stimulating insulin secretion independent of glucose consumption and are administered regardless of meals.
Down
Unlike GLP-1 receptor agonists, DPP4 inhibitors only exert their action on one organ, the (blank).
Meglitinides and sulfonylureas are two examples of oral medication classes that can cause (blank) when used alone, a side effect commonly associated with insulin.
Generic name for Januvia.
This GLP1 receptor agonist is the only once daily, long acting drug in the class.
The maximum effect of this medication is not seen until 8-12 weeks after the start of therapy.
Generic name for Byetta.
This medication is known to reduce the levels of ethinyl estradiol which requires that patients take oral contraceptives at least 4 hours prior to taking this medication.
GLP-1 receptor agonists and DPP4 inhibitors are categorized into a group of medications known as the (blank - 2 words).
This is the only sulfonylurea with active metabolites.
Brand name for semaglutide.