a type of drug that increases the metabolic activity of an enzyme either by binding to the enzyme and activating it, or by increasing the expression of the gene coding for the enzyme.
Per os
a cotransporter and integral membrane protein involved in secondary active transport of two or more different molecules or ions across a phospholipid membrane such as the plasma membrane in the same directions.
a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation
the study of how genes affect a person’s response to drugs.
the circulation of biliary acids, bilirubin, drugs or other substances from the liver to the bile, followed by entry into the small intestine, absorption by the enterocyte and transport back to the liver.
Oxidation, reduction, hydrolytic reactions and the activities of cytochromes
Preventing or reducing the binding or action of a receptor ligand
a substance that initiates a physiological response when combined with a receptor.
The fraction of drug absorbed into the systemic circulation after extravascular administration
linear pharmacokinetics; steady-state serum drug concentrations change proportionally with long-term daily dosing (most common pharmacokinetic model)
Down
the time required for serum concentrations to decrease by one-half after absorption and distribution are complete
Conjugation of initially metabolized drugs to enhance elimination
a generic name for the group of enzymes that are responsible for most drug metabolism oxidation reactions
Primary organ of drug metabolism
pharmacologically inactive drugs that are metabolized to an active state
the discipline that describes the absorption, distribution, metabolism, and elimination (ADME) of drugs in patients requiring drug therapy; what the body does to a drug
a proportionality constant that relates the amount of drug in the body to the serum concentration
nonlinear pharmacokinetics; steady-state serum drug concentrations do not change proportionally with dosing; changes may be more or less than expected
A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it
what a drug does to the body; the study of the biochemical, physiologic, and molecular effects of drugs on the body and involves receptor binding (including receptor sensitivity), postreceptor effects, and chemical interactions
the expected in vivo biological equivalence of two proprietary preparations of a drug
Primary organ of drug elimination
the build-up of a higher concentration of a chemical across a cell membrane due to the pKa value of the chemical and difference of pH across the cell membrane.
a type of drug that decreases the metabolic activity of an enzyme either by binding to the enzyme and deactivating it, or by decreasing the expression of the gene coding for the enzyme.
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Where is my puzzle?
All your puzzles are accessible from your 'My Puzzles' page, which you can access using the navigation bar at the top when you are logged in.
Be sure to log in using the same email address you used when you created your puzzle.
How do I print?
There is a 'Make Printable' button on the top left of your puzzle that will let you sign up for a plan or purchase a single puzzle.
Once paid, that button will turn into a 'Preview + Publish' button that will put your puzzle in a format that can be printed or solved online.
Once you publish your puzzle, you can click the print icon or use your browser’s print function.
It looks weird when printed.
First make sure you’ve published your puzzle. See the 'How do I print?' section above for more information.
99% of other printing issues have to do with printer settings. Instead of trying to fiddle with printer settings, which can be time-consuming and frustrating, there are a couple workarounds you can try.
You can try printing from a different browser, since different browsers have different default print settings. Alternately, you can try saving as a PDF (next to the print icon) and print that.
Why isn’t this free?
We invested in building a number of premium features that free sites are unable to offer: the ability to automatically or manually add words to your puzzle, save-as-you-go puzzle editing, the ability to access your puzzles from any computer, an uncluttered and ad-free interface, the ability for friends and colleagues to solve your puzzles online, and quick responsiveness to reported issues.
My Crossword Maker is the lowest-price service we've found that provides these features, and is designed for people who are not satisfied with what free sites are able to provide.
I thought this was free.
We’re sorry you thought My Crossword Maker was free, that must have been frustrating.
We’re constantly trying to provide a clear and straightforward user experience, and we’re not trying to hide the price: on the page where you make your puzzle, the price is listed in the overview in the top left (before you log in), below the 'Make Printable' button (after you log in), in the FAQ below the grid, and also in the tour.
Unfortunately, we have limited control over how we show up in Google and on other sites, so if they show My Crossword Maker when someone searches for a free site we can’t do anything about that.
It says there is no account with my email.
First check whether you used a different email address to create your account. Your login email is the email address where you received a welcome email from us.
Alternately, it’s possible there was a typo in your email when you created your account. If so, report an issue below and provide the name and last four digits on the card you used when you signed up. We’ll use this information to track down your account.
I am being asked to pay a second time.
If you are a member of My Crossword Maker and are still being asked for payment, then you may have inadvertently created a second account.
Your paid account will have the email address where you received an email confirming your subscription.
If you never received such an email, or are still unable to find your paid account, report an issue below and provide the name and last four digits on the card you used when you signed up. We’ll use this information to track down your account.
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For security a human can’t see or reset your password, so read the below information carefully.
If you haven’t gotten the password reset email, check your spam folder, be sure you’re checking the email account that the email was sent to, and be aware that some school email systems block emails from non-school email addresses.
If you have the password reset email but the password isn’t accepted, be sure you are using the most recent password reset email: sometimes people will hit the button twice, and only the second password will work.
Be sure if you copy-paste the password not to get a space on the outside, or if you're typing it keep in mind that it's case-sensitive and that a lower-case L can look like the number 1, etc.
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Not all my words are in my puzzle.
When you hit the 'Arrange' button, our algorithm will try to arrange all your words on the grid, and will move words around to try to fit the most words.
This will get all the words on the grid about 90% of the time, depending on the word list. For the other 10%, you will get an alert explaining that the words that did not fit were added to the scratchpad.
It prints on two pages.
Big puzzles won’t always print on one page — the clues and grid are the smallest we could make them while keeping them readable for everyone.
That said, different browsers print in slightly different ways, so you could try using 'print preview' using a different browser (or try the PDF button) to see if you like how that looks better.
I didn’t hear back from you.
We generally respond to all reported issues in about a day. If it’s been a few days and you haven’t heard back from us, it’s possible we sent an email that didn’t reach you.
Check your spam folder, and be aware that some school email systems block emails from non-school email addresses. Try providing a different email address if you think our emails to you are being blocked.
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