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The Nature Paper Crossword

Across
GTP binding to KRAS ___signal transduction pathways
KRAS ___ a key signalling protein in tumors.
AMG 510 markedly increased the infiltration of ___ after 4 days.
AMG 510 ____ with immunotherapy
This mutant amino acid resides next to a pocket present in GDP-bound KRAS
AMG 510 tested in combo with this standard of care chemo agent
In normal cells, KRAS alternates between inactive & active states, functioning as this:
AMG 510 is administered by this route
Out of ten mice who received AMG 510 + anti-PD-1 therapy, number that achieved complete responses
AMG 510 induced a ______ tumor microenvironment
KRAS functions as a ____, which catalyzes the conversion of GTP to GDP.
Down
In time course studies, treatment with AMG 510 elicited ____ (>24 hrs) effects on MAPK and EGFR pathway signalling
State in which KRAS is GTP-bound
AMG 510 inhibits ERK-_____ and growth of KRAS G12C-mutant tumors
AMG 510 exploits this, created by alternative orientation to His95, to enhance interactions with the KRAS protein, resulting in enhanced potency & binding
KRAS G12C is this type of mutation
In time course studies, treatment with AMG 510 elicited ___ (<2 hrs) effects on MAPK and EGFR pathway signalling
KRAS binds to this P2____
AMG 510 doesn't inhibit this form of KRAS
Facilitates transition between the active and inactive state of KRAS
State in which KRAS is GDP-bound
How often per day AMG 510 was dosed